Citation
Ferris, M.; Hogan, S.; L; Chin, H.; Shoham, D.; A; Gipson, D.; S; Gibson, K.; & Yilmaz, S., et al. (2007). Obesity, albuminuria, and urinalysis findings in US young adults from the Add Health Wave III study. Clinical Journal of the American Society of Nephrology. vol. 2 (6) pp. 1207-1214Abstract
BACKGROUND AND OBJECTIVES: Obesity has been associated with kidney disease in adults. This study was designed to evaluate the association of obesity with an early marker of kidney disease, albuminuria, among young adults. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Urinalysis (n = 9371), albumin-to-creatinine ratio (n = 4463), and body mass index (kg/m2) were measured in the Add Health Wave III cohort (2001 to 2002), a multiethnic sample of young adults followed for approximately 6 yr. Multivariate logistic regression modeled the association of sex-specific albuminuria with body mass index, adjusted for sample weights, sex, race, ethnicity, and glycosuria. RESULTS: Urinalysis revealed that 0.8% had proteinuria, 4.6% had hematuria, 0.2% had combined hematuria and proteinuria, and 1.5% had glycosuria. Albuminuria prevalence was 4.4%. Mean body mass index was higher among those with albuminuria compared with those without. There were no associations between body mass index categories of 25 to < 30 or 30 to < 35 kg/m2 with albuminuria compared with the lowest body mass index (< 25 kg/m2); however, the highest category (> or = 35 kg/m2) was associated with albuminuria, compared with the lowest category (OR = 1.76, 95% CI: 1.02 to 3.04). Glycosuria (OR = 4.0; 95% CI: 1.5 to 11.1, p < 0.01) as well as increasing body mass index during the 6-yr follow-up (OR: 1.07 per unit change in kg/m2; 95% CI: 1.00 to 1.13, p = 0.04) were also associated with albuminuria. CONCLUSIONS: Given the increasing prevalence of obesity, the association of albuminuria associated with obesity in young adults is particularly concerning. Obesity may be a target for primary prevention of kidney and cardiovascular disease.URL
http://dx.doi.org/10.2215/cjn.00540107Keyword(s)
Adolescent Adult Albuminuria/ epidemiology Body Mass Index Child Chronic Disease Creatinine/urine Female Glycosuria/epidemiology Hematuria/epidemiology Humans Kidney Diseases/etiology Male Obesity/complications/epidemiology/ethnology/ urine Proteinuria/Notes
Ferris, Maria Hogan, Susan L Chin, Hyunsook Shoham, David A Gipson, Debbie S Gibson, Keisha Yilmaz, Sema Falk, Ronald J Jennette, J Charles 3-PO1-DK058335-05S1/DK/NIDDK NIH HHS/United States 5T32HL007055-29/HL/NHLBI NIH HHS/United States P01-HD31921/HD/NICHD NIH HHS/United States P30-DK56350/DK/NIDDK NIH HHS/United States Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't United States Clin J Am Soc Nephrol. 2007 Nov;2(6):1207-14. Epub 2007 Oct 17.Reference Type
Journal ArticleJournal Title
Clinical Journal of the American Society of NephrologyAuthor(s)
Ferris, M.Hogan, S.
L
Chin, H.
Shoham, D.
A
Gipson, D.
S
Gibson, K.
Yilmaz, S.
Falk, R.
J
Jennette, J.
C