Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms

Citation

Rowe, D. C.; Stever, C.; Chase, D.; Sherman, S.; Abramowitz, A.; & Waldman, I. D. (2001). Two dopamine genes related to reports of childhood retrospective inattention and conduct disorder symptoms. Mol Psychiatry. vol. 6 (4) pp. 429-33

Abstract

The 7-repeat allele of the dopamine receptor D4 gene (DRD4) and the 10 repeat allele of the dopamine transporter gene (DAT1) have shown association and linkage with symptoms of attention deficit hyperactivity disorder (ADHD) in childhood. The parents of ADHD children (clinic group, n = 80 fathers and 107 mothers) and control children (control group, n = 42 fathers and 51 mothers) were the focus of this study. These parents reported retrospectively on their level of ADHD Inattention and Conduct Disorder symptoms in adolescence. In analyses of the relation of symptom levels to the DRD4 and DAT1 genotypes, fathers possessing the 7 repeat DRD4 allele had greater levels of both inattention and conduct disorder symptoms. Mothers with the 10/10 genotype had higher levels of inattention symptoms. Thus, genetic associations found in children may be replicable in their parents.

URL

http://dx.doi.org/10.1038/sj.mp.4000874

Keyword(s)

Adult

Notes

Rowe, D C

Reference Type

Journal Article

Journal Title

Mol Psychiatry

Author(s)

Rowe, D. C.
Stever, C.
Chase, D.
Sherman, S.
Abramowitz, A.
Waldman, I. D.

Year Published

2001

Volume Number

6

Issue Number

4

Pages

429-33

Edition

2001/07/10

ISSN/ISBN

1359-4184 (Print)

DOI

10.1038/sj.mp.4000874

Reference ID

1799