CitationWickrama, Kandauda; O'Neal, Catherine Walker; & Lee, Tae Kyoung (2013). Early Community Context, Genes, and Youth Body Mass Index Trajectories: An Investigation of Gene–Community Interplay Over Early Life Course. Journal of Adolescent Health. vol. 53 (3) pp. 328-334
AbstractPurpose To investigate additive and interactive influences of community adversity and cumulative genetic sensitivity on youth body mass index (BMI) trajectories over adolescence and young adulthood. Methods We used latent growth curve modeling to examine BMI trajectories over three waves (1995, 2001, and 2008) of the National Longitudinal Study of Adolescent Health (n = 14,563). We measured genetic sensitivity by a cumulative index of genes associated with serotonin and dopamine functions. Results Community adversity was positively associated with the initial level and rate of change in BMI trajectories over time. Adolescents experiencing community adversity had a higher BMI at Wave 1 and gained weight more quickly than those who did not live in adverse communities. Community adversity interacted with cumulative genetic sensitivity to explain variation in the rate of change in BMI trajectories. The influence of community adversity was greater for those with more sensitivity alleles than those with fewer sensitivity alleles. Gender, race/ethnicity, and family contexts were also associated with youth BMI trajectories. Conclusions Community adversity in early adolescence, and its interaction with genes, has far-reaching consequences, including the rate of change in BMI trajectories extending into adulthood. This work has practical implications for future intervention/prevention programs.
Reference TypeJournal Article
Journal TitleJournal of Adolescent Health
O'Neal, Catherine Walker
Lee, Tae Kyoung