The metabolic burden of sleep loss

Citation

Schmid, Sebastian M.; Hallschmid, Manfred; & Schultes, Bernd (2014). The metabolic burden of sleep loss. The Lancet Diabetes & Endocrinology. vol. 3 (1) pp. 52-62

Abstract

In parallel with the increasing prevalence of obesity and type 2 diabetes, sleep loss has become common in modern societies. An increasing number of epidemiological studies show an association between short sleep duration, sleep disturbances, and circadian desynchronisation of sleep with adverse metabolic traits, in particular obesity and type 2 diabetes. Furthermore, experimental studies point to distinct mechanisms by which insufficient sleep adversely affects metabolic health. Changes in the activity of neuroendocrine systems seem to be major mediators of the detrimental metabolic effects of insufficient sleep, through favouring neurobehavioural outcomes such as increased appetite, enhanced sensitivity to food stimuli, and, ultimately, a surplus in energy intake. The effect of curtailed sleep on physical activity and energy expenditure is less clear, but changes are unlikely to outweigh increases in food intake. Although long-term interventional studies proving a cause and effect association are still scarce, sleep loss seems to be an appealing target for the prevention, and probably treatment, of metabolic disease.

URL

http://dx.doi.org/10.1016/S2213-8587(14)70012-9

Reference Type

Journal Article

Journal Title

The Lancet Diabetes & Endocrinology

Author(s)

Schmid, Sebastian M.
Hallschmid, Manfred
Schultes, Bernd

Year Published

2014

Volume Number

3

Issue Number

1

Pages

52-62

ISSN/ISBN

2213-8587

DOI

http://dx.doi.org/10.1016/S2213-8587(14)70012-9

Reference ID

4896