Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts

Citation

Sanz-de-Galdeano, A.; Terskaya, A.; & Upegui, A. (2020). Association of a genetic risk score with BMI along the life-cycle: Evidence from several US cohorts. PLoS One. vol. 15 (9)

Abstract

We use data from the National Longitudinal Study of Adolescent to Adult Health and from the Health and Retirement Study to explore how the effect of individuals' genetic predisposition to higher BMI -measured by BMI polygenic scores- changes over the life-cycle for several cohorts. We find that the effect of BMI polygenic scores on BMI increases significantly as teenagers transition into adulthood (using the Add Health cohort, born 1974-83). However, this is not the case for individuals aged 55+ who were born in earlier HRS cohorts (1931-53), whose life-cycle pattern of genetic influence on BMI is remarkably stable as they move into old-age.

URL

https://doi.org/10.1371/journal.pone.0239067

Keyword(s)

adolescent

Reference Type

Journal Article

Journal Title

PLoS One

Author(s)

Sanz-de-Galdeano, A.
Terskaya, A.
Upegui, A.

Year Published

2020

Volume Number

15

Issue Number

9

ISSN/ISBN

1932-6203

DOI

10.1371/journal.pone.0239067

Reference ID

5964