Latent class analysis of adolescent substance use and antisocial behaviors comorbidity: Gene-environment interplay and gender differences

Citation

Su, Jinni & Supple, Andrew J. (2014). Latent class analysis of adolescent substance use and antisocial behaviors comorbidity: Gene-environment interplay and gender differences. 2014 Add Health Users Conference. Bethesda, MD.

Abstract

Using a person-centered approach, this study aims at examining co-morbidity typologies of substance use and antisocial behaviors among adolescents and gene-environment interplay in relation to co-morbidity typologies. Given past research suggesting gender differences in substance use and antisocial behaviors, gender differences in co-morbidity typologies will also be explored. Genetic factors considered in this study include the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (5-HTTLPR) collected at Wave IV in Add Health. Environmental factors considered will be childhood maltreatment (retrospective measure at Wave III), and parental warmth (adolescent-report at Wave I). Latent class analysis will be conducted using MPlus to examine co-morbidity typologies, using dichotomized substance use and antisocial behaviors measured at Wave I as indicators. Analyses will be conducted separately for males and females. It is expected that a large proportion of adolescents will be classified into a typology characterized by low risk for engagement in any substance use and antisocial behaviors and other adolescents will be classified into typologies characterized by risk for engagement in different combinations of substance use and antisocial behaviors. It is also hypothesized that genetic factors and environmental factors will interact in influencing adolescents' likelihood of being classified in different comorbidity typologies.

URL

https://addhealth.cpc.unc.edu/wp-content/uploads/docs/events/20140613_Add_Health_Users_Conference_Abstracts.pdf

Reference Type

Conference proceeding

Book Title

2014 Add Health Users Conference

Author(s)

Su, Jinni
Supple, Andrew J.

Year Published

2014

City of Publication

Bethesda, MD

Reference ID

6237