Developmental gene-environment interplay in adult antisocial behaviors


Li, James J. (2016). Developmental gene-environment interplay in adult antisocial behaviors. 2016 Add Health Users Conference. Bethesda, MD.


Behavioral genetic studies have indicated that aggressive and non-aggressive rule-breaking subtypes of antisocial behavior (ASB) are etiologically separable, with unique genetic and environmental risk factors that may differentially predict adult outcomes (Niv et al., 2014; Kendler, Aggen, & Patrick, 2013; Burt, 2009). Using a vantage sensitivity framework, the current investigation tests the association between aggregate genetic sensitivity scores (using additive and dominance models across candidate genes in the dopamine and serotonin systems) with early maltreatment exposure (risk factor) and self-reported childhood family support (enrichment factor) in the prediction of Wave IV adult ASB. Preliminary results indicate that adults maltreated as children who had high genetic sensitivity scores had more antisocial behaviors than maltreated adults with lower genetic sensitivity scores. Genetic sensitivity scores did not interact with childhood family support in predicting their adult ASB. The follow-up examination investigates whether the association between maltreatment exposure and adult ASB among the high genetic sensitivity group is mediated by aggressive and/or non-aggressive rule-breaking subtypes of ASB using latent growth curve analysis of ASB items from Waves I-III. It is hypothesized that this association will be mediated by the aggressive developmental subtype of ASB, given previous behavioral genetic evidence of higher genetic influences underlying the aggressive subtype.


Reference Type

Conference proceeding

Book Title

2016 Add Health Users Conference


Li, James J.

Year Published


City of Publication

Bethesda, MD

Reference ID