Citation
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M.; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; & Tian, Chao, et al. (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics. vol. 51 pp. 237-244Abstract
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6–11. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures.URL
https://doi.org/10.1038/s41588-018-0307-5Reference Type
Journal ArticleJournal Title
Nature GeneticsAuthor(s)
Liu, MengzhenJiang, Yu
Wedow, Robbee
Li, Yue
Brazel, David M.
Chen, Fang
Datta, Gargi
Davila-Velderrain, Jose
McGuire, Daniel
Tian, Chao
Zhan, Xiaowei
Agee, Michelle
Alipanahi, Babak
Auton, Adam
Bell, Robert K.
Bryc, Katarzyna
Elson, Sarah L.
Fontanillas, Pierre
Furlotte, Nicholas A.
Hinds, David A.
Hromatka, Bethann S.
Huber, Karen E.
Kleinman, Aaron
Litterman, Nadia K.
McIntyre, Matthew H.
Mountain, Joanna L.
Northover, Carrie A. M.
Sathirapongsasuti, J. Fah
Sazonova, Olga V.
Shelton, Janie F.
Shringarpure, Suyash
Tian, Chao
Tung, Joyce Y.
Vacic, Vladimir
Wilson, Catherine H.
Pitts, Steven J.
Mitchell, Amy
Skogholt, Anne Heidi
Winsvold, Bendik S.
Sivertsen, Børge
Stordal, Eystein
Morken, Gunnar
Kallestad, Håvard
Heuch, Ingrid
Zwart, John-Anker
Fjukstad, Katrine Kveli
Pedersen, Linda M.
Gabrielsen, Maiken Elvestad
Johnsen, Marianne Bakke
Skrove, Marit
Indredavik, Marit Sæbø
Drange, Ole Kristian
Bjerkeset, Ottar
Børte, Sigrid
Stensland, Synne Øien
Choquet, Hélène
Docherty, Anna R.
Faul, Jessica D.
Foerster, Johanna R.
Fritsche, Lars G.
Gabrielsen, Maiken Elvestad
Gordon, Scott D.
Haessler, Jeffrey
Hottenga, Jouke-Jan
Huang, Hongyan
Jang, Seon-Kyeong
Jansen, Philip R.
Ling, Yueh
Mägi, Reedik
Matoba, Nana
McMahon, George
Mulas, Antonella
Orrù, Valeria
Palviainen, Teemu
Pandit, Anita
Reginsson, Gunnar W.
Skogholt, Anne Heidi
Smith, Jennifer A.
Taylor, Amy E.
Turman, Constance
Willemsen, Gonneke
Young, Hannah
Young, Kendra A.
Zajac, Gregory J. M.
Zhao, Wei
Zhou, Wei
Bjornsdottir, Gyda
Boardman, Jason D.
Boehnke, Michael
Boomsma, Dorret I.
Chen, Chu
Cucca, Francesco
Davies, Gareth E.
Eaton, Charles B.
Ehringer, Marissa A.
Esko, Tõnu
Fiorillo, Edoardo
Gillespie, Nathan A.
Gudbjartsson, Daniel F.
Haller, Toomas
Harris, Kathleen Mullan
Heath, Andrew C.
Hewitt, John K.
Hickie, Ian B.
Hokanson, John E.
Hopfer, Christian J.
Hunter, David J.
Iacono, William G.
Johnson, Eric O.
Kamatani, Yoichiro
Kardia, Sharon L. R.
Keller, Matthew C.
Kellis, Manolis
Kooperberg, Charles
Kraft, Peter
Krauter, Kenneth S.
Laakso, Markku
Lind, Penelope A.
Loukola, Anu
Lutz, Sharon M.
Madden, Pamela A. F.
Martin, Nicholas G.
McGue, Matt
McQueen, Matthew B.
Medland, Sarah E.
Metspalu, Andres
Mohlke, Karen L.
Nielsen, Jonas B.
Okada, Yukinori
Peters, Ulrike
Polderman, Tinca J. C.
Posthuma, Danielle
Reiner, Alexander P.
Rice, John P.
Rimm, Eric
Rose, Richard J.
Runarsdottir, Valgerdur
Stallings, Michael C.
Stančáková, Alena
Stefansson, Hreinn
Thai, Khanh K.
Tindle, Hilary A.
Tyrfingsson, Thorarinn
Wall, Tamara L.
Weir, David R.
Weisner, Constance
Whitfield, John B.
Winsvold, Bendik Slagsvold
Yin, Jie
Zuccolo, Luisa
Bierut, Laura J.
Hveem, Kristian
Lee, James J.
Munafò, Marcus R.
Saccone, Nancy L.
Willer, Cristen J.
Cornelis, Marilyn C.
David, Sean P.
Hinds, David A.
Jorgenson, Eric
Kaprio, Jaakko
Stitzel, Jerry A.
Stefansson, Kari
Thorgeirsson, Thorgeir E.
Abecasis, Gonçalo
Liu, Dajiang J.
Vrieze, Scott
andMe Research, Team
Psychiatry, Hunt All-In