Role of Inflammatory Liability in Modifying the Relationship between Stressful Life Events and Depressive Symptomology

Citation

Gaydosh, Lauren; Cole, Steve; Shanahan, Michael J.; Levitt, Brandt; & Harris, Kathleen M. (2019). Role of Inflammatory Liability in Modifying the Relationship between Stressful Life Events and Depressive Symptomology. Population Association of America annual meeting. Austin, TX.

Abstract

There is a large literature documenting a robust association between major stressful life events and depression and depressive symptoms. While inflammation has been suggested as a potential biological mechanism linking stressful life exposures and depression, this link remains unclear. In this paper, we used data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to test the role of inflammatory liability in moderating the link between stressful life events and depressive symptomology. We found preliminary evidence that the increase in depressive symptoms associated with greater cumulative stressful life events is steeper for individuals with a gene expression profile of increase inflammatory liability.

URL

http://paa2019.populationassociation.org/abstracts/191751

Reference Type

Conference proceeding

Book Title

Population Association of America annual meeting

Author(s)

Gaydosh, Lauren
Cole, Steve
Shanahan, Michael J.
Levitt, Brandt
Harris, Kathleen M.

Year Published

2019

City of Publication

Austin, TX

Reference ID

7297