Gene Expression in Pre-Disease Pathways: The Importance of Life Course Patterns of BMI

Citation

Pontente, Cecilia; Shanahan, Micheal; Chumbley, Justin; Cole, Steve; Gaydosh, Lauren; Levitt, Brandt; & Harris, Kathleen M. (2019). Gene Expression in Pre-Disease Pathways: The Importance of Life Course Patterns of BMI. Population Association of America annual meeting. Austin, TX.

Abstract

High levels of obesity in the United States and rising trends worldwide call for attention to the role of life course patterns of body mass index (BMI) in pre-disease pathways. Using recently collected mRNA abundance data in Wave 5 of the National Longitudinal Study of Adolescent to Adult Health (Add Health), this study examines how life course patterns of BMI are related to gene expression markers of important health outcomes in later life, including cardiac infarction, type 2 diabetes, and immune/inflammatory functioning as indicated by the conserved transcriptional response to adversity signature (CTRA). We test hypotheses using a Bayesian approach concerning different life course models: accumulation, critical, and sensitive periods. Preliminary results show a strong association between Wave V BMI and gene expression scores related to infarction and type 2 diabetes among people who have not had an infarction and do not have diabetes type 2, respectively.

URL

http://paa2019.populationassociation.org/abstracts/193096

Reference Type

Conference proceeding

Book Title

Population Association of America annual meeting

Author(s)

Pontente, Cecilia
Shanahan, Micheal
Chumbley, Justin
Cole, Steve
Gaydosh, Lauren
Levitt, Brandt
Harris, Kathleen M.

Year Published

2019

City of Publication

Austin, TX

Reference ID

7316