Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood

Citation

Bares, C. B.; Kendler, K. S.; & Maes, H. H. (2015). Developmental Changes in Genetic and Shared Environmental Contributions to Smoking Initiation and Subsequent Smoking Quantity in Adolescence and Young Adulthood. Twin Research and Human Genetics. vol. 18 (5) pp. 497-506

Abstract

BACKGROUND: Few studies examining the genetic architecture of cigarette smoking have focused on adolescents or examined developmental changes in additive genetic, shared environment, and unique environmental influences on liability to initiate cigarette smoking and quantity of cigarettes smoked. The aim of this study was to add to the literature on liability to initiate and use cigarettes during adolescence using a nationally representative sample. METHOD: Data for this study came from adolescent and young adult twin pairs (aged 14-33 years) from the National Longitudinal Study of Adolescent to Adult Health. We ran a series of developmental causal-contingent-common pathway models to examine whether additive genetic, shared, and unique environmental influences on liability to the initiation of cigarette use are shared with those on smoking quantity, and whether their contributions change across development. RESULTS: We found evidence for a developmental shift in genetic and shared environmental contributions to cigarette use. Early in adolescence, genetic and environmental influences work independently on liability to cigarette smoking initiation and quantity of cigarettes smoked, but liability to these behaviors becomes correlated as individuals age into young adulthood. CONCLUSIONS: These findings provide insight into the causal processes underlying the liability to smoke cigarettes. With age, there is greater overlap in the genetic and environmental factors that influence the initiation of cigarette smoking and quantity of cigarettes smoked.

URL

http://dx.doi.org/10.1017%2Fthg.2015.48

Keyword(s)

adolescents cigarette smoking development environmental influences genetic influences

Notes

Bares, Cristina B Kendler, Kenneth S Maes, Hermine H Journal article Twin Res Hum Genet. 2015 Jul 31:1-10.

Reference Type

Journal Article

Journal Title

Twin Research and Human Genetics

Author(s)

Bares, C. B.
Kendler, K. S.
Maes, H. H.

Year Published

2015

Volume Number

18

Issue Number

5

Pages

497-506

ISSN/ISBN

1832-4274 (Print) 1832-4274

DOI

10.1017/thg.2015.48

NIHMSID

NIHMS703985

Reference ID

7719