Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Citation

Williams, Redford B.; Bishop, George D.; Haberstick, Brett C.; Smolen, Andrew; Brummett, Beverly H.; Siegler, Ilene C.; Babyak, Michael A.; Zhang, Xiaodong; Tai, E. Shyong; & Lee, Jeannette, et al. (2017). Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence. American Heart Journal. vol. 185 pp. 110-122

Abstract

Background Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in two large, nationally representative samples in the U.S. and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L'S′, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In U.S. Whites L’ allele carriers had higher SBP (0.9 mmHg, 95%CI = 0.26, 1.56) and greater odds (odds ratio [OR] = 1.23, 95%CI = 1.10, 1.38) of more severe hypertension than those with S′S′ genotypes. In African Americans, L’ carriers had lower mean SBP (−1.27 mmHg, 95% CI = −2.53, −0.01) and lower odds (OR =0.78, 95% CI = 0.65, 0.94) of more severe hypertension than those with the S′S′ genotype. In African Americans, those with L'L’ genotypes had lower DBP (−1.13 mmHg, 95% CI = −2.09, −0.16) than S′ carriers. In Native Americans, L’ carriers had lower SBP (−6.05 mmHg, 95% CI = −9.59, −2.51) and lower odds of hypertension (OR =0.34, 95% CI = 0.13, 0.89) than those with the S′S′ genotype. In Asian/Pacific Islanders those carrying the L’ allele had lower DBP (−1.77 mmHg, 95%CI = −3.16,-0.38) and lower odds of hypertension (OR =0.68, 95%CI = 0.48, 0.96) than those with S′S′. In the Singapore sample S′ carriers had higher SBP (3.02 mmHg, 95%CI = 0.54, 5.51) and DBP (1.90 mmHg, 95%CI = 0.49, 3.31) than those with the L'L’ genotype. Conclusions These findings suggest that Whites carrying the L’ allele, African Americans and Native Americans with the S′S′ genotype, and Asians carrying the S′ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.

URL

http://dx.doi.org/10.1016/j.ahj.2016.12.013

Keyword(s)

serotonin transporter

Reference Type

Journal Article

Journal Title

American Heart Journal

Author(s)

Williams, Redford B.
Bishop, George D.
Haberstick, Brett C.
Smolen, Andrew
Brummett, Beverly H.
Siegler, Ilene C.
Babyak, Michael A.
Zhang, Xiaodong
Tai, E. Shyong
Lee, Jeannette
Jen-Mai Tan, Maudrene
Teo, Yik Ying
Cai, Shiwei
Chan, Edmund
Halpern, Carolyn Tucker
Whitsel, Eric A.
Bauldry, Shawn
Harris, Kathleen Mullan

Year Published

2017

Volume Number

185

Pages

110-122

Edition

December 29, 2016

DOI

10.1016/j.ahj.2016.12.013

NIHMSID

NIHMS864186

Reference ID

8245