Citation
Belsky, Daniel W.; Domingue, Benjamin W.; Wedow, Robbee; Arseneault, Louise; Boardman, Jason D.; Caspi, Avshalom; Conley, Dalton; Fletcher, Jason M.; Freese, Jeremy; & Herd, Pamela, et al. (2018). Genetic analysis of social-class mobility in five longitudinal studies. Proceedings of the National Academy of Sciences.Abstract
Genome-wide association study (GWAS) discoveries about educational attainment have raised questions about the meaning of the genetics of success. These discoveries could offer clues about biological mechanisms or, because children inherit genetics and social class from parents, education-linked genetics could be spurious correlates of socially transmitted advantages. To distinguish between these hypotheses, we studied social mobility in five cohorts from three countries. We found that people with more education-linked genetics were more successful compared with parents and siblings. We also found mothers’ education-linked genetics predicted their children’s attainment over and above the children’s own genetics, indicating an environmentally mediated genetic effect. Findings reject pure social-transmission explanations of education GWAS discoveries. Instead, genetics influences attainment directly through social mobility and indirectly through family environments.A summary genetic measure, called a “polygenic score,” derived from a genome-wide association study (GWAS) of education can modestly predict a person’s educational and economic success. This prediction could signal a biological mechanism: Education-linked genetics could encode characteristics that help people get ahead in life. Alternatively, prediction could reflect social history: People from well-off families might stay well-off for social reasons, and these families might also look alike genetically. A key test to distinguish biological mechanism from social history is if people with higher education polygenic scores tend to climb the social ladder beyond their parents’ position. Upward mobility would indicate education-linked genetics encodes characteristics that foster success. We tested if education-linked polygenic scores predicted social mobility in >20,000 individuals in five longitudinal studies in the United States, Britain, and New Zealand. Participants with higher polygenic scores achieved more education and career success and accumulated more wealth. However, they also tended to come from better-off families. In the key test, participants with higher polygenic scores tended to be upwardly mobile compared with their parents. Moreover, in sibling-difference analysis, the sibling with the higher polygenic score was more upwardly mobile. Thus, education GWAS discoveries are not mere correlates of privilege; they influence social mobility within a life. Additional analyses revealed that a mother’s polygenic score predicted her child’s attainment over and above the child’s own polygenic score, suggesting parents’ genetics can also affect their children’s attainment through environmental pathways. Education GWAS discoveries affect socioeconomic attainment through influence on individuals’ family-of-origin environments and their social mobility.URL
https://doi.org/10.1073/pnas.1801238115Reference Type
Journal ArticleJournal Title
Proceedings of the National Academy of SciencesAuthor(s)
Belsky, Daniel W.Domingue, Benjamin W.
Wedow, Robbee
Arseneault, Louise
Boardman, Jason D.
Caspi, Avshalom
Conley, Dalton
Fletcher, Jason M.
Freese, Jeremy
Herd, Pamela
Moffitt, Terrie E.
Poulton, Richie
Sicinski, Kamil
Wertz, Jasmin
Harris, Kathleen Mullan