Citation
Domingue, Benjamin W.; Rehkopf, David H.; Conley, Dalton; & Boardman, Jason D. (2018). Geographic clustering of polygenic scores at different stages of the life course. RSF: The Russell Sage Foundation Journal of the Social Sciences. vol. 4 (4) pp. 137-149Abstract
We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent’s state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual’s educational attainment net of that person’s polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.URL
https://doi.org/10.7758/RSF.2018.4.4.08Keyword(s)
polygenic scores,genetics,geographyReference Type
Journal ArticleJournal Title
RSF: The Russell Sage Foundation Journal of the Social SciencesAuthor(s)
Domingue, Benjamin W.Rehkopf, David H.
Conley, Dalton
Boardman, Jason D.