Intergenerational pathways linking maternal early life adversity to offspring birthweight


Kane, Jennifer B.; Harris, Kathleen Mullan; & Siega-Riz, Anna Maria (2018). Intergenerational pathways linking maternal early life adversity to offspring birthweight. Social Science and Medicine. vol. 207 pp. 89-96


Adverse birth outcomes can lead to problematic long-term outcomes for children, and are also known to transmit socioeconomic disadvantage across generations, thereby amplifying the importance of identifying their social determinants. However, the full set of factors causing adverse birth outcomes remains unknown. Drawing together theory describing intragenerational (life course) processes linking early life adversity to adult health, and intergenerational transmissions of inequality via birthweight, this study tests a chain of risk that originates within early adolescence, impacts young women's risky health behaviors in late adolescence/early adulthood and risky health behaviors during pregnancy, and ultimately decreases offspring's birthweight. We do so using structural equation models and prospective, population-level data on a racially and socioeconomically diverse cohort of young adults (National Longitudinal Study of Adolescent to Adult Health). Results (a) reveal four pathways that fully mediate the association between a young woman's family-of-origin socioeconomic status in adolescence and her offspring's birthweight, and (b) identify a trigger effect—a place in the chain of risk where prevention efforts could be targeted, thereby breaking the chain of risk leading to poor offspring health at birth for vulnerable individuals.



Intergenerational Birthweight Preconception Life course Prenatal smoking Adolescent smoking Population health US

Reference Type

Journal Article

Journal Title

Social Science and Medicine


Kane, Jennifer B.
Harris, Kathleen Mullan
Siega-Riz, Anna Maria

Year Published


Volume Number





April 30, 2018



Reference ID