The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco

Citation

Zeiger, J.; Haberstick, B. C.; Schlaepfer, I.; Collins, A. C.; Corley, R. P.; Crowly, T. J.; & Hewitt J. K, Hopfer C. J. Lessem J. McQueen M. B. Rhee S. H. Ehringer M. A. (2008). The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco. Human Molecular Genetics. vol. 17 (5) pp. 724-734

Abstract

Neuronal nicotinic acetylcholine receptors have been implicated in various measures of nicotine dependence. In this paper, we present findings from an exploratory study of single nucleotide polymorphisms (SNPs) in the CHRNB3 and CHRNA6 genes with tobacco and alcohol phenotypes, including frequency of use and three subjective response factors occurring shortly after initiation of use. Subjects were 1056 ethnically diverse adolescents ascertained from clinical and community settings. The most significant associations were found between two CHRNB3 SNPs (rs4950 and rs13280604) and the three subjective response factors to initial tobacco use. These findings were replicated in a separate community sample of 1524 families participating in the National Longitudinal Study of Adolescent Health. Both CHRNB3 SNPs were found to be associated with similar measures of subjective response to tobacco. These results indicate that early subjective response to nicotine may be a valuable endophenotype for genetic studies aimed at uncovering genes contributing to nicotine use and addiction.

URL

http://dx.doi.org/10.1093%2Fhmg%2Fddm344

Keyword(s)

Genetic

Reference Type

Journal Article

Journal Title

Human Molecular Genetics

Author(s)

Zeiger, J.
Haberstick, B. C.
Schlaepfer, I.
Collins, A. C.
Corley, R. P.
Crowly, T. J.
Hewitt J. K, Hopfer C. J. Lessem J. McQueen M. B. Rhee S. H. Ehringer M. A.

Year Published

2008

Volume Number

17

Issue Number

5

Pages

724-734

DOI

10.1093/hmg/ddm344

Reference ID

787