Detecting genetic heterogeneities in response to trauma: The case of 9/11

Citation

Furuya, Shiro; Fletcher, Jason M.; Zhao, Zijie; Sun, Zhongxuan; & Lu, Qiongshi (2022). Detecting genetic heterogeneities in response to trauma: The case of 9/11. SSM - Mental Health. vol. 2

Abstract

The current study evaluates genetic heterogeneities in response to trauma among U.S. young adults. Using Add Health Wave III, which coincidently overlapped with the September 11 attacks, and a depression mean and variance polygenic scores, we investigate how the polygenic scores moderate the causal effect of 9/11 on mental health. Our results show the presence of genetic heterogeneity, where those with high genetic plasticity experience an increase in depressive symptoms following trauma while those with low genetic plasticity do not. While the documented differences in reactions to trauma are important, we also note our ability to predict responses based only on genetic measures are too imprecise to identify susceptible clinical patients. We, therefore, contend that the expected benefits from genetic screening to identify susceptible individuals after trauma are limited. Our results provide novel evidence of a specific source of an additional heterogeneity contributing to the inequality of health following trauma.

URL

https://doi.org/10.1016/j.ssmmh.2021.100044

Keyword(s)

Diathesis stress model

Reference Type

Journal Article

Journal Title

SSM - Mental Health

Author(s)

Furuya, Shiro
Fletcher, Jason M.
Zhao, Zijie
Sun, Zhongxuan
Lu, Qiongshi

Year Published

2022

Volume Number

2

ISSN/ISBN

2666-5603

DOI

10.1016/j.ssmmh.2021.100044

Reference ID

9482